Description
Product Characteristics: Apoptosis regulator Bcl-2, B-cell CLL/lymphoma-2,Bcl-2 (Apoptosis & Follicular Lymphoma Marker)
Cellular localisation: Outer mitochondrial membranes and endoplasmic reticulum as well as nuclear membranes.
Target Information: This gene encodes an integral outer mitochondrial membrane protein that blocks the apoptotic death of some cells such as lymphocytes. Constitutive expression of BCL2, such as in the case of translocation of BCL2 to Ig heavy chain locus, is thought to be the cause of follicular lymphoma. Two transcript variants, produced by alternate splicing, differ in their C-terminal ends. [provided by RefSeq, Jul 2008]